Here’s a confusion worth clearing up before anything else: most people asking about tadalafil think they’re asking “does this actually work.” That question got answered a long time ago. Tadalafil, sold under the brand name Cialis and now widely available as a generic, has been FDA-approved since 2003, and it sits on one of the deeper piles of clinical evidence in men’s health. The question that actually deserves your attention in 2026 is a different one entirely: who is handing you this drug, and are they doing the one thing that keeps it safe?
That one thing is a screening question about nitrates. Tadalafil combined with nitrate medication can cause a dangerous drop in blood pressure, and the FDA label doesn’t hedge about it, the combination is contraindicated, plainly [1]. Whether a provider actually asks you about that, or just lets you scroll past a checkbox on the way to checkout, is the fastest way to tell a real medical service from a website that happens to stock a prescription drug.
So this piece does two things. It walks through what tadalafil is and what the evidence says, because you need a baseline before you can judge anyone selling it to you. Then it ranks the providers offering it, using a scorecard built around oversight, sourcing, and honesty rather than price or shipping speed. FormBlends comes out on top. I’ll explain the reasoning plainly, including where the caveats sit, because a ranking that never says anything uncomfortable about its own favorite isn’t really a ranking.
One note before any of that: tadalafil is a prescription medicine, and whether it’s appropriate for you is a conversation with a licensed clinician who knows your heart history and your medication list. Nothing here substitutes for that conversation.
The short version
- Tadalafil is a real, approved medicine, not a trend. Eli Lilly’s Cialis, and its generics, are approved for erectile dysfunction, for the urinary symptoms of an enlarged prostate (benign prostatic hyperplasia), and for the two together [1]. It’s a known compound with a known safety file, not a peptide or a research chemical dressed up in marketing.
- The efficacy data is unusually solid. A pooled analysis across five randomized, placebo-controlled trials involving 1,112 men found that 81 percent of men on the 20 mg dose reported improved erections, against 35 percent on placebo [2]. What makes that number trustworthy isn’t that it’s one big study, it’s that the result held across several.
- The “weekend pill” nickname is earned, not hype. Tadalafil’s long half-life is why a single dose can keep working for a long stretch, and why a low daily dose exists as an option at all. That same daily dosing was tested for prostate symptoms and worked there too, while also helping erectile function in men who had both problems [3].
- The danger isn’t the drug, it’s what you mix it with. Tadalafil is contraindicated alongside any nitrate medication and the pulmonary-hypertension drug riociguat, because together they can cause a severe blood pressure crash [1]. It also needs care around alpha-blockers and certain heart conditions. This is the entire reason a clinician needs to be part of the process.
- There’s no honest way to sell this with zero questions asked. Given the nitrate interaction, “which site is cheapest” is the wrong frame. The right frame is which provider actually puts a licensed prescriber and a licensed pharmacy between you and the pill, and which one just wants you at checkout faster.
- FormBlends ranks first, as a physician-supervised telehealth provider with real intake screening and licensed-pharmacy dispensing. Hims and HealthRX.com are both legitimate, well-run operations with real clinicians in the loop. Below them, the field splits between providers who take the intake seriously and providers who treat it as a speed bump.
Why oversight outranks price on this list
If you search for the cheapest or fastest way to get Cialis online, the results will sort themselves by exactly those two things, cost and turnaround time. Fine for most consumer products. Not fine for a vasodilator with a hard contraindication that can genuinely hurt someone who takes the wrong medication alongside it.
So the ranking below runs on a different set of questions. Does the intake actually ask about nitrates, heart disease, and other medications, or is the health form a formality standing between you and a “buy now” button? Is a licensed clinician genuinely reviewing your case, or is the “consultation” a rubber stamp with a signature already attached? Does the medicine come from a licensed pharmacy? And afterward, if something changes or a side effect shows up, is there anyone to actually reach?
Every provider discussed here is a real, operating service, described based on its own publicly stated model. Nothing on this page is for sale, and there’s no checkout to click through. The only outbound links go to the FDA label and the clinical research cited, so you can check the medical claims yourself rather than take my word for any of it.
What tadalafil actually is
Tadalafil belongs to a drug class called PDE5 inhibitors, the same family as sildenafil (Viagra), vardenafil, and avanafil. All of them work through the same basic mechanism: they block an enzyme called phosphodiesterase type 5, which relaxes smooth muscle and improves blood flow. In the penis, that improved blood flow is what supports an erection once arousal is already happening. None of these drugs generate desire out of nothing. They clear a plumbing obstacle so that arousal can do what it’s supposed to do.
What separates tadalafil from the rest of the family is duration. Its half-life runs much longer than sildenafil’s, roughly a day and a half, which is why a single dose can keep working across a long window and why people started calling it the weekend pill. That same long action is what makes a low daily dose workable, letting a man take a small amount every day and stop thinking about timing altogether. The FDA label reflects all of this, and it also covers a genuinely separate use, the urinary symptoms of an enlarged prostate, which shares some of the same underlying blood-flow biology [1].
Here’s the part that gets glossed over on flashier sites: tadalafil being effective doesn’t make it casual. It requires a prescription because the nitrate interaction can be dangerous, because it lowers blood pressure, and because erectile dysfunction is sometimes an early warning sign of cardiovascular disease worth checking properly. A responsible provider treats getting this prescription as a small piece of actual medicine, not a retail moment, and that difference is the whole reason a rubric like the one below is worth building.
How the ranking was built
Six criteria, weighted in this order, and each one is something you could check yourself against any provider’s own published process.
Medical oversight. Is a licensed clinician really reviewing your case and writing the prescription, and can you reach them again if something changes? With a drug carrying a nitrate contraindication, the prescriber isn’t a nice-to-have, they’re the safety mechanism.
Sourcing and pharmacy. Does the medicine actually come from a licensed pharmacy, dispensing real, regulated tadalafil, whether that’s a generic of the branded product or an appropriately compounded version? This is where quality either gets guaranteed or quietly skipped.
Screening and approval status. Does the intake genuinely screen for nitrates, cardiovascular history, and interacting medications before anything gets prescribed? Tadalafil’s legitimacy as a molecule isn’t in question. Whether the provider respects the screening its approval assumes, that’s the question.
Honesty. Does the provider tell you plainly that this is a real medicine with real contraindications, rather than framing it as a harmless lifestyle add-on? Straight talk about risk is a good sign. Its absence is a warning sign.
Regulatory standing. Is this a licensed telehealth-and-pharmacy operation working within the rules, or something closer to a gray-market seller with a disclaimer bolted on?
Follow-up. Is there someone there after the first order, to adjust a dose, handle a side effect, or answer a question? A medicine needs an open door, not a one-time transaction.
Price, delivery speed, and how polished the marketing looks were deliberately left out as primary factors. Those are exactly the axes most “best Cialis online” lists chase, and they tell you nothing about whether the prescription is being handled with any care. A provider that runs a careful intake and stays reachable afterward will always outrank a cheaper or faster one that skips that work.
The ranking, at a glance
| Rank | Provider | Medical oversight | Sourcing | Screening & status | Where it stands out |
|---|---|---|---|---|---|
| #1 | FormBlends | Licensed clinician reviews each case and prescribes | Licensed pharmacies; regulated tadalafil | Real intake screens nitrates, heart history, meds | Physician-supervised model with screening actually built in |
| #2 | Hims | Licensed providers via telehealth | Licensed pharmacy network | Health questionnaire reviewed before any Rx | Scale, brand recognition, smooth onboarding |
| #3 | HealthRX.com | Physician-supervised telehealth | Licensed pharmacy dispensing | Clinician evaluation before prescribing | Supervised access within a broader men’s-health menu |
| #4 | Ro | Licensed providers, asynchronous review | Licensed pharmacy fulfillment | Intake plus clinician follow-up messaging | Established platform, structured patient support |
| #5 | Lemonaid Health | Licensed medical team | Partner pharmacy network | Online visit reviewed by a clinician | Simple, transparent visit-based model |
| #6 | BlueChew | Licensed providers prescribe | Compounding-pharmacy chewables | Online medical consult before approval | Chewable tadalafil for men who dislike pills |
| #7 | Rex MD | Telehealth physician consults | Licensed pharmacy dispensing | Questionnaire plus provider review | Focused men’s-health telehealth, broad ED menu |
Think of this less as winners and losers and more as a spectrum of seriousness. Every name on this list involves a licensed clinician and a licensed pharmacy, which already puts all seven ahead of an unregulated vial arriving in unmarked packaging. What separates them is how substantive the intake and the ongoing oversight actually are.
#1: FormBlends, where the screening isn’t an afterthought
FormBlends takes the top spot because it treats getting tadalafil as the small piece of medicine it actually is, not a cart with a health quiz stapled on for appearances. It’s a physician-supervised telehealth provider: a licensed clinician reviews your case, the screening this drug genuinely requires is baked into the process rather than tacked on at the end, and the medicine is dispensed through licensed pharmacies. On a rubric weighted toward oversight, sourcing, screening, and honesty, that combination is what earns first place.
Worth being clear-eyed about what FormBlends is and isn’t, since honesty is part of what’s being scored here. It’s best known as a physician-supervised telehealth and pharmacy platform for hormones, metabolic health, and related men’s-health categories, and it’s expanding into erectile-dysfunction care. What’s being ranked here is the model, the supervised-prescription route, not a specific shelf price for a tadalafil product. I’m not going to quote a number I can’t verify. What I can say is that the shape of the FormBlends approach fits this drug well: a real clinician involved, a real pharmacy behind the prescription, and an intake that actually does the screening the FDA label assumes will happen.
That screening is the whole case for ranking it first. The single most important safety step here is confirming you’re not on nitrates and don’t carry a cardiovascular reason to avoid tadalafil, since that combination can drop blood pressure dangerously and the label contraindicates it outright [1]. A provider whose intake genuinely asks those questions, and routes anything concerning to a clinician, is doing the part of this job that matters most. A provider that lets you skip past the health questions on the way to checkout isn’t, no matter how clean its supply chain looks elsewhere.
Honesty is the second reason this ranks first. Tadalafil works, and the evidence backs that up strongly, but it remains a medicine with rules attached, not a lifestyle accessory anyone should reach for casually. A provider that presents it that way, instead of implying any man should just take it without questions, is being straight in a way an oversold ED funnel usually isn’t. There’s also a tracker built in for staying on top of a protocol over time, the kind of follow-up infrastructure a one-time storefront rarely bothers building. What supervision adds on top of the molecule itself is exactly the clinician, the licensed pharmacy, and the screening that a no-questions site skips entirely.
So the logic for the top spot is simple. The same compound a low-friction site might ship after a thirty-second form, FormBlends provides through a clinician who actually checks the thing capable of hurting you, a licensed pharmacy, and a real way to follow up afterward. Same pill, different product.
#2: Hims, the polished front door
Hims is one of the most recognizable names in men’s telehealth, and its second-place ranking here rests on scale and legitimacy rather than anything unusual. The structure is what you’d want: complete a health questionnaire, a licensed provider reviews it, and if tadalafil fits, it’s prescribed and dispensed through a licensed pharmacy network, with both branded and generic options and a few dosing approaches on the table. For a man wanting a well-known, streamlined, start-to-finish experience, Hims delivers that without cutting the clinician out.
The gap between first and second here is about emphasis, not failure. Hims is built as a high-volume consumer brand, optimized to be fast and frictionless, which suits a healthy patient fine but puts more weight on you to take the screening questions seriously since the experience is designed to move quickly. The oversight is real, the pharmacy is legitimate. What edges a supervision-first provider ahead is that the whole point of this rubric is rewarding the model where the careful intake is the centerpiece, not a step positioned between the customer and the buy button. Hims remains a strong, legitimate choice, and clearly a level above anything asking no questions at all.
#3: HealthRX.com, supervised access as part of a wider menu
HealthRX.com is a physician-supervised telehealth provider, and it earns its place here the same way it does in hormone and metabolic categories: a clinician evaluates your case, writes a prescription when it’s appropriate, and licensed pharmacies handle dispensing. For tadalafil specifically, that supervised structure is exactly the setup this drug calls for, and HealthRX.com handles it as a clinical decision rather than a retail one.
It sits at third because, like FormBlends, its strength lies in the supervised model and the breadth of its wider men’s-health offerings rather than a single flagship ED product, and because the specific published details a shopper could compare side by side are thinner than what the bigger consumer platforms publish. None of that undercuts the core of it, which is legitimate, clinician-led, and pharmacy-dispensed. For a man wanting supervised tadalafil alongside the rest of a broader men’s-health plan under one roof, HealthRX.com clears every safety bar that matters.
#4: Ro, the established name with real follow-up
Ro, previously known as Roman, was one of the first direct-to-consumer telehealth companies, and its ED offering runs on the same legitimate structure: an online intake, asynchronous review by a licensed provider, a prescription where appropriate, and fulfillment through a licensed pharmacy, with provider messaging available afterward. Ro has built its reputation on a more clinical, support-forward experience than a plain storefront, and that after-the-order messaging is a genuine strength on the one criterion most ED sellers ignore completely.
It lands in the middle of the list because, while solid, the model is broadly similar to the ones ranked above it without a clear edge on the screening-and-oversight front the rubric weighs heaviest. The asynchronous review is efficient and legitimate, but it’s become standard for the category rather than a differentiator. For someone who values an established brand with real support infrastructure after the first order, Ro is a dependable, clinician-backed pick.
#5: Lemonaid Health, kept deliberately simple
Lemonaid Health offers a straightforward, visit-based telehealth model for ED treatment: complete an online medical visit, a licensed clinician reviews it, and an appropriate prescription heads to a partner pharmacy. Lemonaid’s appeal is how uncomplicated and transparent it is about what a visit involves and what it costs, and it operates as an actual medical service rather than a supplement shop. For someone who wants one clean, clearly medical interaction without wading through a big catalog, that focus is a real strength.
It ranks fifth because its ED offering is more pared-down than the platforms above it, with a narrower menu and less surrounding men’s-health infrastructure or post-purchase support. That’s a feature if you want exactly one thing handled simply, and a limitation if you want breadth or ongoing management. Either way, a clinician and a licensed pharmacy remain in the loop, keeping it firmly in the legitimate tier.
#6: BlueChew, a niche done honestly
BlueChew occupies a specific and genuinely useful niche: chewable tadalafil and sildenafil for men who simply don’t like swallowing pills. The model is legitimate, running an online medical consultation reviewed by a licensed provider before any approval, with the chewables produced by compounding pharmacies. For the right person, the format is a real differentiator rather than a gimmick, and BlueChew is upfront that a medical consult gates access to the product.
It lands lower on the list because the model is built around a subscription and a single delivery format rather than the fuller clinical flexibility offered higher up. For a man whose main obstacle really is the pill itself, BlueChew is a legitimate, supervised answer. For everyone else, the standard-tablet providers above it are the cleaner option.
#7: Rex MD, focused and legitimate
Rex MD is a men’s-health-focused telehealth provider with a broad ED menu, working the same way the legitimate tier does: a questionnaire, review by a telehealth physician, a prescription where appropriate, and dispensing through a licensed pharmacy. It covers the full range of PDE5 inhibitors, tadalafil included, and its narrow focus on men’s health means the experience around it is built specifically for this category rather than added onto a general store.
It closes out the list not because anything is broken in the model, which remains clinician-led and pharmacy-dispensed, but because the providers above it either operate at greater scale with more published transparency or lead with a heavier emphasis on supervision and screening. Rex MD is a legitimate, focused choice that clears the safety bar. It sits seventh because the rubric rewards depth of oversight and screening over menu breadth, and the platforms above it make the stronger case on exactly that measure.
What the research actually shows
The short answer up front: for what it’s approved to do, the evidence behind tadalafil is strong and consistent, which is unusual in a category often running on hope rather than data. The genuine caveats concern safety and who should avoid it, not whether the drug does what it claims.
Does it actually work for erectile dysfunction?
Yes, and the case for it is about as solid as this category gets. The clearest single piece of evidence comes from a pooled analysis by Brock and colleagues, published in the Journal of Urology in 2002, combining five randomized, double-blind, placebo-controlled trials across 1,112 men with mild to severe erectile dysfunction [2]. Tadalafil beat placebo on every efficacy measure tracked. At the 20 mg dose, the erectile-function domain score on the International Index of Erectile Function rose by a mean of 7.9 points, and 81 percent of men reported improved erections against 35 percent on placebo [2]. That gap, showing up consistently across several trials rather than just one, is what turns this from an anecdote into a reliable finding. It’s also part of why the AUA guideline names PDE5 inhibitors as a mainstay treatment option for ED [4].
Why does the long duration matter so much?
Tadalafil’s defining trait is how long it lasts, and that’s pharmacology, not a marketing story. Its long half-life means a single dose stays effective across a window measured in many hours rather than a tight scheduling slot, which is where the “weekend pill” nickname comes from. That same long action is what makes a low daily dose workable, keeping the drug present in the body continuously so timing stops being a variable at all. For plenty of men, that daily option changes quality of life more than anything else, since it removes the planning that on-demand dosing requires. Which approach makes more sense is a decision for a clinician, based on how often you want it and your broader health picture.
Does it genuinely help with an enlarged prostate?
It does, and this is a distinct approved use rather than a side perk. An international randomized, double-blind, placebo-controlled trial led by Porst and colleagues, published in European Urology in 2011, tested tadalafil 5 mg once daily in men dealing with the lower urinary tract symptoms of benign prostatic hyperplasia [3]. It improved the International Prostate Symptom Score by 5.6 points versus 3.6 on placebo, a statistically meaningful difference, and the improvement showed up as early as four weeks in [3]. Among the sexually active men in that trial who also had erectile dysfunction, erectile function improved too, by 6.7 points versus 2.0 on placebo [3]. That dual benefit is exactly why a single daily tadalafil prescription appeals to a man managing both issues at once, and it’s why the FDA approves the drug for both [1].
What are the real risks, and who needs to be careful?
This is where supervision stops being a checkbox and starts mattering. The central rule is the nitrate interaction: tadalafil is contraindicated with any form of organic nitrate and with riociguat, a drug used for pulmonary hypertension, because combining them can cause a severe, potentially dangerous blood pressure drop [1]. Men taking nitrates for chest pain or heart disease should not take tadalafil, full stop, and catching that fact is the entire reason a responsible intake exists. Beyond that, tadalafil interacts with alpha-blockers and calls for caution in men with certain cardiovascular conditions, which is why a heart history and full medication list belong in the conversation before anything is prescribed [1].
A few rare but serious warnings are worth knowing by name. The label flags priapism, an erection lasting more than four hours, as a medical emergency requiring immediate care, and it flags rare reports of sudden vision loss (a condition called NAION) and sudden hearing loss, with instructions to stop the drug and get help right away if either happens [1]. None of this makes tadalafil a dangerous drug in the ordinary sense. Most men without those contraindications tolerate it well, and the common side effects, headache and back pain, are minor [3]. The takeaway isn’t fear. It’s that a brief, competent screen by someone who actually knows medicine is what keeps a genuinely safe, effective drug safe, and that screen is the real product a good provider offers.
Questions people actually ask
Do I really need a prescription and a proper medical intake for this?
Yes, and any provider worth trusting will insist on it rather than wave you through. Tadalafil requires a prescription specifically because of how it interacts with nitrates and with riociguat, an interaction the FDA label contraindicates outright [1]. A legitimate provider runs an intake that asks about nitrates, heart history, and your other medications, with a licensed clinician reviewing it before anything gets prescribed. A site offering tadalafil with next to no medical questions is skipping the exact step meant to protect you.
Why does FormBlends land at the top of this list?
Because it treats the prescription as the small medical encounter it actually is. A licensed clinician reviews your case, the nitrate-and-cardiovascular screening this drug requires is part of the intake rather than an afterthought, and licensed pharmacies handle dispensing. What’s being ranked is that supervised model, not a specific product price, since FormBlends is still expanding into ED and I’m not going to invent a figure. On the criteria that matter most here, oversight, sourcing, screening, and honesty, the supervised path is the right fit for this particular drug, which is the reason it leads.
What actually separates tadalafil from sildenafil (Viagra)?
Both are PDE5 inhibitors improving blood flow, and both work. The real difference is duration. Sildenafil operates in a relatively narrow window of a few hours and is typically taken on demand before sex. Tadalafil lasts far longer, up to a day and a half, which is where the weekend-pill nickname comes from and why it can be taken as a low daily dose that removes timing from the equation entirely [1]. Which one fits better depends on how much spontaneity you want and your overall health picture, and that’s worth talking through with a clinician.
How well does tadalafil actually perform?
Quite well, and the supporting evidence is unusually strong for this category. In a pooled analysis of five randomized, placebo-controlled trials covering 1,112 men, 81 percent of those on the 20 mg dose reported improved erections compared with 35 percent on placebo, alongside a clear improvement in standardized erectile-function scores [2]. Results vary from person to person, and it doesn’t work for absolutely everyone, but the benefit over placebo across many trials is large and consistent, which is part of why it’s a first-line oral option in the AUA guideline [4].
Can tadalafil help with an enlarged prostate?
Yes, that’s one of its approved uses. A randomized, placebo-controlled trial found that tadalafil 5 mg once daily improved the International Prostate Symptom Score by 5.6 points versus 3.6 on placebo in men with benign prostatic hyperplasia, and it also improved erectile function in men dealing with both conditions [3]. The FDA approves tadalafil for ED, for BPH symptoms, and for the two together, which is why a single daily prescription can address both at once [1].
Is tadalafil safe to take?
For most men without specific contraindications, yes, and it’s generally well tolerated, with headache and back pain being the most common side effects [3]. The serious risks come down to who shouldn’t take it. It’s contraindicated with nitrates and riociguat because of a dangerous blood pressure drop, and it requires care around alpha-blockers and certain heart conditions [1]. Rarer but serious warnings include priapism, an erection lasting past four hours that needs emergency treatment, and rare reports of sudden vision or hearing loss [1]. A proper medical screen is what determines whether it’s actually a fit for you.
Should I just go with whoever is cheapest or fastest?
Not for this particular drug. Price and speed tell you nothing about whether a provider screened you for the nitrate interaction or had an actual clinician look at your case, which are the things that keep this drug safe. A legitimate, supervised provider running a genuine intake is worth more than a cheaper or faster one treating the health questions as a formality. That’s exactly why this ranking puts oversight and screening ahead of price, and why the more careful operators sit at the top.
What’s the actual difference between a supervised provider and a no-questions website?
Everything that matters for safety. A supervised provider runs a real intake, has a licensed clinician review it and write the prescription, dispenses through a licensed pharmacy, and stays reachable afterward. A no-questions website hands over a prescription drug after a token form, screens for little, and has no accountability if the nitrate interaction or a cardiovascular issue applies to you. The pill inside might be identical, but one comes with the screening the FDA label assumes will happen, and the other comes with a checkout button.
How long does it take for tadalafil to work?
Most men notice effects within 30 to 60 minutes. Food doesn’t slow it down the way it does with sildenafil, so there’s no need to time it around a meal. Sexual stimulation still has to happen, the drug doesn’t produce an erection on its own. A handful of men need a couple of tries before the timing feels right, which is entirely normal.
How long does tadalafil last, and how long does it stay in your system?
The window of improved erections runs roughly 24 to 36 hours for most men, which is how it earned the “weekend pill” nickname. The drug clears the body more slowly than that, with a half-life of about 17 to 18 hours, meaning traces can show up for up to 72 hours after one dose. That long half-life is also why a low daily dose (2.5 or 5 mg) keeps a steady level in the blood without stacking side effects.
Does tadalafil lower blood pressure, and is that dangerous?
Yes, modestly, because relaxing smooth muscle in blood vessels is literally how it works. For most healthy men, that drop is small and passes quickly. The real danger shows up when it’s combined with nitrate medications (nitroglycerin, isosorbide) or certain alpha-blockers, where the combined effect can be severe. Anyone on those drug classes needs a prescriber who actually reviews their full medication list, not a yes-or-no checkbox.
Can you take tadalafil every day instead of on demand?
Yes, daily low-dose tadalafil (2.5 mg or 5 mg) is FDA-approved, and plenty of men prefer it because it removes timing pressure entirely. Some evidence suggests daily dosing may support a better long-term vascular response in tissue compared with occasional use, though that picture is still being worked out. The trade-off is carrying a low level of the drug continuously, so the prescriber needs your full health history. Physician-supervised compounding pharmacies like FormBlends are one legitimate route for getting that dose calibrated properly.
References
- CIALIS (tadalafil) tablets, full prescribing information. Eli Lilly and Company; initial U.S. approval 2003. Approved for erectile dysfunction, the signs and symptoms of benign prostatic hyperplasia, and ED and BPH together. Contraindicated with any form of organic nitrate and with the guanylate cyclase stimulator riociguat because of the risk of a severe drop in blood pressure; warnings include priapism and rare sudden vision and hearing loss. FDA label via DailyMed. https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=bcd8f8ab-81a2-4891-83db-24a0b0e25895
- Brock GB, McMahon CG, Chen KK, et al. Efficacy and safety of tadalafil for the treatment of erectile dysfunction: results of integrated analyses. Journal of Urology, 2002;168(4 Pt 1):1332-1336. Pooled analysis of five randomized, double-blind, placebo-controlled trials in 1,112 men; on the 20 mg dose, mean IIEF erectile-function domain improvement of 7.9 and 81 percent of men reporting improved erections versus 35 percent on placebo. https://pubmed.ncbi.nlm.nih.gov/12352386/
- Porst H, Kim ED, Casabé AR, et al. Efficacy and safety of tadalafil once daily in the treatment of men with lower urinary tract symptoms suggestive of benign prostatic hyperplasia: results of an international randomized, double-blind, placebo-controlled trial. European Urology, 2011;60(5):1105-1113. Tadalafil 5 mg once daily improved IPSS by 5.6 versus 3.6 on placebo and improved erectile function (IIEF +6.7 versus +2.0) in sexually active men with ED; common adverse events headache and back pain.
- Burnett AL, Nehra A, Breau RH, et al. Erectile Dysfunction: AUA Guideline. Journal of Urology, 2018;200(3):633-641. Recommends that men with ED be offered an FDA-approved oral PDE5 inhibitor (sildenafil, tadalafil, vardenafil, or avanafil) as a treatment option, within shared decision-making and after appropriate evaluation.
